2011 Dec;162(6):959-65. doi: 10.1016/j.ahj.2011.09.012. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Clinical research shows daily supplementation with Pycnogenol® may help improve circulation, normalize blood pressure and maintain healthy cholesterol levels. Blood pressure can be low for those reasons mainly, it's usually one of these four reasons.-Dehydration Clinical trials and studies with groups receiving either placebo or French Maritime Pine Bark Extracts show the tremendous potential of such products. Results revealed that the supplement, known as pycnogenol, reduces blood pressure considerably more than placebo after eight weeks. Pycnogenol is a popular natural supplement with many uses. Healthy blood pressure and circulation Pycnogenol helps maintain healthy circulation by optimizing the release of chemicals from endothelial cells, cells that line arteries and veins, which can improve their function, improve blood flow and also contribute to maintaining healthy blood pressure. der Marke Pycnogenol®) ist ein gut erforschtes Naturheilmittel mit breitem Anwendungsspektrum. Furthermore, blood pressure, heart rate and respiratory rates were improved among patients. Clipboard, Search History, and several other advanced features are temporarily unavailable. Supplementation of the patients with 100 mg Pycnogenol over a … Pycnogenol® beneficially modulates nitric oxide production. ... Yu-Lu WEI, Zhang ZhengXing Tong, Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis, June 2018 Iranian Journal of Public Health; Hinweis zu Gesundheitsthemen. Pycnogenol normalises high blood pressure. « The effect of Pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Hypertension, 55(6): 1373–80. Report No. Studies have also shown that Pycnogenol® enhances the body’s own response to counteract blood vessel constriction. Effect of pycnogenol supplementation on blood pressure: A systematic review and meta-analysis of clinical trials. Pycnogenol senkt Blutdruck und hilft in den Wechseljahren. HHS -, Masquelier J, Michaud J, Laparra J, Dumon MC. This not only has the effect of lowering hypertension and blood pressure but also improving LDL cholesterol levels and general circulation. The study also shows Pycnogenol® is effective for improving blood pressure in patients with metabolic syndrome. Keywords: Crit Rev Food Sci Nutr. Results: GENEVA, Switzerland – A recent study published in Panminerva Medica reveals that a Pycnogenol ® and Coenzyme Q10 (CoQ10) combination (PycnoQ10 ®) taken by stable heart failure patients as an adjunct to medical treatment naturally strengthens the heart, increasing the blood volume ejected with each beat. Conclusion: Supplementation of the patients with 100 mg Pycnogenol over a period of 12 weeks helped to reduce the dose o … The improved endothelial function achieved with Pycnogenol allows for healthier vasodilatation that, in turns, helps to normalise elevated blood pressure. This not only has the effect of lowering hypertension and blood pressure but also improving LDL cholesterol levels and general circulation. Pycnogenol (pic-noj-en-all) is an antioxidant plant extract from the bark of the French maritime pine tree and has been clinically proven to improve endothelial function and blood flow. Written by Greg Arnold, DC, CSCS. Rezzani R, Porteri E, De Ciuceis C, et al. Remember, if you are going to try alternative forms of medication , … (2010). Background: Pycnogenol exhibits many biological activities, including control of blood pressure (BP). Conflict of interest The authors declare that there is no conflict of interest. Yet, the most significant and performance limiting interplay is taking place between the cardio-respiratory system and skeletal muscle. USA.gov. Pourmasoumi M, Hadi A, Mohammadi H, Rouhani MH. Pycnogenol has been demonstrated in various previous studies to have a favorable effect for normalizing blood pressure, and this effect has been attributed to an improved endothelial function. Leg cramps. Pycnogenol is used for treating circulation problems, allergies, asthma, ringing in the ears, high blood pressure, muscle soreness, pain, osteoarthritis, diabetes, attention deficit- hyperactivity disorder (ADHD), a disease of the female reproductive system called endometriosis, menopausal symptoms, painful menstrual periods, erectile dysfunction (ED), and an eye … Nitric oxide (NO) relaxes constricted blood vessels and normalises blood pressure. COVID-19 is an emerging, rapidly evolving situation. Blood Pressure and Bloodstream Side Effects blood pressure image by palms from Fotolia.com According to a 1999 article in "Free Radical Biology and Medicine," pine bark extract inhibits the activity of angiotensin-converting enzyme, or ACE, an … Pycnogenol supplementation significantly reduced blood pressure and blood sugar in 58.3% of 48 diabetic and hypertensive subjects within 12 weeks compared to 20.8% in the control group. Effect of Pycnogenol on Blood Pressure: Findings From a PRISMA Compliant Systematic Review and Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled, Clinical Studies. Epub 2015 May 29. Epub 2018 Jan 23. Front Endocrinol (Lausanne). Mirtogenol® Eye Health Supplement Lowers Intraocular Pressure and Improves Blood Flow. J Cardiovasc Pharmacol Ther. If your blood pressure is low for a different reason, then you need to figure out what that is. Best bet is to drink more water, eat more fat, salt, and get a decent amount of carbs but emphasizing protein in a 4:1 ratio with the carbs. 3.5 Blood Pressure. This meta-analysis with nine trials provides better evidence that Pycnogenol exerts beneficial effects on BP. Please enable it to take advantage of the complete set of features! Either a fixed-effects or, in the presence of heterogeneity, a random-effects model was used to calculate the effect of combined treatment. Effect of probiotic fermented milk on blood pressure: a meta-analysis of randomised controlled trials. (2015). 2019;59(10):1605-1618. doi: 10.1080/10408398.2017.1422480. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Pycnogenol® in metabolic syndrome and related disorders. A placebo-controlled, double-blind, parallel group study was performed with 58 patients to investigate effects of French maritime pine bark extract, Pycnogenol, on patients with hypertension. Methods: This literature search of PubMed, the Web of … The patients were assessed by having their blood samples drawn, blood pressure measured and any adverse events recorded. Study Shows Pycnogenol Naturally Reduces Blood Pressure And Counteracts Kidney Damage Caused By… Study Shows Pycnogenol® Naturally Reduces Cardiovascular Risk Factors in Diabetics Pycnogenol® Delays Glucose Absorption 190 Times More Potently than Prescription Medication Pycnogenol® Reduces Diabetic Microangiopathy Pine tree bark reduces diabetic leg ulcers Type II … As Pycnogenol manages to control blood pressure, you can rest assured that you have an ally for your kidneys’ health. Additionally, because of Pycnogenol’s effect on increasing NO production in the arteries, thus relaxing arterial walls, it provides the same benefit as antihypertensive drugs, which also … 22 Insight into how Pycnogenol® works to lower blood pressure comes … Pycnogenol can be taken for treating circulation problems, allergies, asthma, ringing in the ears, high blood pressure, muscle soreness, pain, osteoarthritis, diabetes, attention deficit hyperactivity disorder (ADHD), a disease of the female reproductive system called endometriosis, menopausal symptoms, painful menstrual periods, erectile dysfunction, and an eye disease called … As a major cause of heart disease and stroke, diabetes affects an estimated 25.8 million Americans (8.3% of the population) (1). Pinienrindenextrakt (z.B. One of the first studies to investigate the effects of pine bark extracts on blood pressure found that taking 200mg Pycnogenol per day for eight weeks lowered systolic blood pressure from the hypertensive range (140 mmHg to … -. -, Gulati OP. See this image and copyright information in PMC. Thus, a meta-analysis was conducted to examine the effect of Pycnogenol supplementation on BP. 2020 Dec 21;11:590392. doi: 10.3389/fendo.2020.590392. Systolic Blood Pressure and Morphological Parameters of Mesenteric Small Resistance Arteries in the Different Groups. 6 Supplementation can also reduce the fluid accumulation that is a common side effect of blood pressure medications. In humans, Pycnogenol has been shown to lower blood pressure in mild to moderate hypertensive individuals and blood glucose levels in diabetics. Effect of pycnogenol supplementation on blood pressure: A systematic review and meta-analysis of clinical trials. 2016 Jun;35(3):615-25. doi: 10.1016/j.clnu.2015.05.012. -. Phytother Res. 2020 Jan;34(1):67-76. doi: 10.1002/ptr.6515. Flavonoides and pycnogenols. Epub 2013 Dec 16. 2001. Pycnogenol has been shown in vitro to protected endothelial cells from oxidative damage, scavenge hydrogen peroxide and other radicals, and enhance intracellular antioxidant mechanisms.  |  Would you like email updates of new search results? Patnode CD, Evans CV, Senger CA, Redmond N, Lin JS. Blood pressure. 1999 (2) Hosseini S et al. Pycnogenol was investigated in a double-blind, placebo-controlled … Therefore, we aimed to assess the impact of pycnogenol on BP through a systematic review of literature and meta-analysis of available randomized, double-blind, placebo-controlled clinical studies (randomized clinical trials [RCTs]). The mixed results suggest that pycnogenol blood-pressure lowering effects may be dependent on the underlying cause of hypertension. Blood pressure; Meta-analysis; Pycnogenol; Randomized controlled trial. However, the reported results are inconsistent because of varied characteristics of participants and quality of studies. Pycnogenol may have benefits for heart and artery health. 20/05/10 Mirtogenol® Eye Health Supplement Lowers Intraocular Pressure and Improves Blood Flow . 27 In endothelial cells, Pycnogenol® boosts levels of endothelial nitric oxide synthase (eNOS), the enzyme system that produces vessel-relaxing nitric oxide in response to blood flow and blood pressure. Study shows pine bark reduces blood pressure, counteracts kidney damage caused by hypertension Research reveals Pycnogenol lowers elevated urinary protein levels and improves blood … Pycnogenol is a French maritime pine bark extract that contains natural antioxidants. Several other medical studies have suggested a value of Pycnogenol in reducing abnormally high blood pressure (2,3) . Qorbani M, Sanginabadi M, Mohajeri-Tehrani MR, Karimi S, Gerami H, Mahdavi-Gorabi A, Shirzad N, Samadi M, Baygi F, Hosseini S, Mansour A. 2020 Feb 11;21(1):162. doi: 10.1186/s13063-019-4008-x. Also medication dosage was decreased by 50%. NIH ‡P<0.001 vs untreated SHRs. NIH Fogacci F, Tocci G, Sahebkar A, Presta V, Banach M, Cicero AFG. Pycnogenol treatment lowered the ACE-inhibitor dose required to control blood pressure, … WMD, weighted mean difference, Funnel plot of Pycnogenol supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP). As a consequence, the oxygen-rich blood supply to the organs …  |  Evaluation of the effects of pycnogenol (French maritime pine bark extract) supplementation on inflammatory biomarkers and nutritional and clinical status in traumatic brain injury patients in an intensive care unit: A randomized clinical trial protocol. Phytother Res. Normalizing blood vessel diameter naturally helps maintain blood pressure that is already in the normal range. Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials. (1979). Int J Vitam Nutr Res, 49(3):307–11. Studies have examined Pycnogenol’s effects on vascular endothelial cells, blood pressure, platelet function, and other measures of health. Trials. Pycnogenol supplements demonstrate antioxidant effects may stimulate the immune system and potentially improve blood flow in research. Overall, the impact of pycnogenol on BP was reported in 7 trials involving 626 participants. 3.5 Blood Pressure. Pycnogenol exhibits many biological activities, including control of blood pressure (BP).
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